Hello Friends 👋,

This week's journal club focuses on a few topics. We have three articles discussing sepsis-related topics. The first articles compared the sensitivity of the EOS calculator and the NICE/Dutch guidelines for the evalution of early onset sepsis. Daphna reviewed a paper from Pediatrics that looked out how many infants with low-risk for EOS were evaluated for sepsis, started on antibiotics and how long were they on antibiotics for (very interesting work from our friend Dustin Flannery). We also reviewed a  paper proposing an interesting framework to approach "culture negative" sepsis. Other than sepsis, we reviewed two papers from both 🇫🇷 and 🇨🇳 looking at the effect of vitamin D levels on neonatal RDS. To close the show we discussed the latest report of the neonatal research network (https://neonatal.rti.org) that published its outcomes from 2013-2018, so much interesting data in that paper.

We hope you enjoy this episode. Thank you for listening and for your support.

As always, feel free to send us questions, comments or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through instagram or twitter, @nicupodcast. Or contact Ben and Daphna directly via their twitter profiles: @drnicu and @doctordaphnamd. Papers discussed in today's episode are listed and timestamped below.


Neonatal early-onset infections: Comparing the sensitivity of the neonatal early-onset sepsis calculator to the Dutch and the updated NICE guidelines in an observational cohort of culture-positive cases
The sensitivity of the EOSC in identifying cases of EOD is lower compared to bothDutch and NICE guidelines, especially directly after birth. The EOSC relies more onclinical symptoms and results in less overtreatment of healthy newborns at the costof later antibiotic treatment in initially well-ap…
Delivery Characteristics and the Risk of Early-Onset Neonatal Sepsis
10.1542/6282514618001Video AbstractPEDS-VA_2021-0529006282514618001BACKGROUND AND OBJECTIVES:. Multiple strategies are used to identify newborn infants at high risk of culture-confirmed early-onset sepsis (EOS). Delivery characteristics have been used to identify preterm infants at lowest risk of in…
A proposed framework for the clinical management of neonatal “culture-negative” sepsis
Neonatal septicemia (sepsis) remains a major cause of worldwide morbidity and mortalityamong term and preterm infants. The term “sepsis” originates from the Greek meaning“to rot.” The modern term came into use in 1914 and meant a change in symptomatologycaused by infection and identified by a set…
Low Vitamin D Levels at Birth and Early Respiratory Outcome in Infants With Gestational Age Less Than 29 Weeks
BackgroundVitamin D (VitD) is involved in lung development but its influence on respiratory distress syndrome of extremely preterm (EPT) infants have been little investigated. In this study, we examined the influence of low vitamin D status at birth on early respiratory outcomes of this vulnerable i…
Association Between Vitamin D Level and Neonatal Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis
BackgroundIn recent years, vitamin D in the occurrence of lung diseases has gradually become a hot topic. Although the role of vitamin D in normal lung development has been confirmed, the correlation between vitamin D level and neonatal respiratory distress syndrome (NRDS) is not clear.ObjectiveTo e…
Mortality, Care Practices, and Other Outcomes for Extremely Preterm Infants in the US, 2013-2018
This prospective observational study assesses mortality, in-hospital morbidity, care practices, and 2-year outcomes among US infants born at 22-28 weeks’ gestational age in 2013-2018 and compares these outcomes with those of a similar cohort of infants born in 2008-2012.

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