Hello team! đź‘‹

Join us this week as we discuss a variety of topics. We review a paper looking at whether supplemental vitamin D could help reduce BPD. Daphna goes over a paper from Australia assessing factors that would help successful extubation after steroids. We are looking at how altitude affects neonatal survival. There are a few HIE papers and we review an article that may have an explain why babies catch less Covid-19 than adults.

Enjoy this journal club and let us know if you have any feedback or recommendations.

Articles discussed in this week's episode are listed below (in chronological order):

Effects of early Vitamin D supplementation on the prevention of bronchopulmonary dysplasia in preterm infants
BackgroundBronchopulmonary dysplasia (BPD) is a respiratory dysfunction caused by poor lung bronchial development, which may lead to long-term lung disease, threatening the lives of children. Studi...
Factors associated with successful extubation following the first course of systemic dexamethasone in ventilator dependent preterm infants with or at risk of developing bronchopulmonary dysplasia
ObjectivesWe aimed to identify factors present at the start of an initial course of systemic dexamethasone that would be associated with successful extubation in mechanically ventilated neonates <3...
Is a higher altitude associated with shorter survival among at-risk neonates?
Introduction We hypothesize that high altitudes could have an adverse effect on neonatal health outcomes, especially among at-risk neonates. The current study aims to assess the association between higher altitudes on survival time among at-risk neonates. Methods Retrospective survival analysis. S…
Effects of tactile stimulation on spontaneous breathing during face mask ventilation
Objective We sought to determine the effect of stimulation during positive pressure ventilation (PPV) on the number of spontaneous breaths, exhaled tidal volume (VTe), mask leak and obstruction. Design Secondary analysis of a prospective, randomised trial comparing two face masks. Setting Single-c…
Outcomes of neonatal hypoxic-ischaemic encephalopathy in centres with and without active therapeutic hypothermia: a nationwide propensity score-matched analysis
Objective Therapeutic hypothermia (TH) for neonatal hypoxic-ischaemic encephalopathy (HIE), delivered mainly in tertiary cooling centres (CCs), reduces mortality and neurodisability. It is unknown if birth in a non-cooling centre (non-CC), without active TH, impacts short-term outcomes. Design Retr…
Physiological responses to cuddling babies with hypoxic–ischaemic encephalopathy during therapeutic hypothermia: an observational study
Objectives To determine whether parents cuddling infants during therapeutic hypothermia (TH) would affect cooling therapy, cardiorespiratory or neurophysiological measures. The secondary aim was to explore parent–infant bonding, maternal postnatal depression and breastfeeding. Design Prospective ob…
Nasal expression of SARS-CoV-2 entry receptors in newborns
Background SARS-CoV-2 infection is typically mild in children. Lower expression of SARS-CoV-2 entry receptors in the nasal epithelia have been described in children compared with adults. However, data from newborns are lacking. We compared nasal expression of four SARS-CoV-2 entry receptors between…

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